Isopropylamine → HCID 59208314, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[C:3]([C:16]2[S:17][CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:20]=2)=[CH:4][C:5]([NH:8][C:9](=[O:15])OC(C)(C)C)=[N:6][CH:7]=1.[CH:25]([NH2:28])([CH3:27])[CH3:26]>C(#N)C>[Br:1][C:2]1[C:3]([C:16]2[S:17][CH:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[N:20]=2)=[CH:4][C:5]([NH:8][C:9]([NH:28][CH:25]([CH3:27])[CH3:26])=[O:15])=[N:6][CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 130 °C
Versuchsvorschrift
A mixture of tert-butyl 5-bromo-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-2-ylcarbamate (Intermediate 87, 25 g, 59 mmol), isopropyl amine (250 mL) and acetonitrile (100 mL) was heated at 130° C. in a Parr Bomb apparatus for 50 h (˜150 PSI). The reaction mixture was cooled to room temperature and the reaction filtered through Celite, and the filtrate was washed with tetrahydrofuran (˜300 mL). The solvents were evaporated and the residue was triturated with methanol (200 mL), filtered and the solid was dried to give 14.6 g of product.