1-(4-Benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one → (R)-2-hydroxy-4-methyl-1-(piperazin-1-yl)pentan-1-one

HRID 2062183

Reaktionsgleichung

Reaktionsgleichung von HRID 2062183
C([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:21])[CH:15]([OH:20])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[OH:20][C@H:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:21]

Komponenten

4

Edukt 1

HCID 670984871-(4-Benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one

Produkt 1

HCID 59216548(R)-2-hydroxy-4-methyl-1-(piperazin-1-yl)pentan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-(4-benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one (132 g) in methanol (1 L) was added Pd/C (20 g, 10% weight Pd on carbon). The reaction mixture was stirred at room temperature overnight under an atmosphere of hydrogen. The reaction mixture was filtered through Celite, and the solvent was removed in vacuo. (R)-2-Hydroxy-4-methyl-1-piperazin-1-yl-pentan-1-one was obtained as an oil (68 g, 74%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ffa6fa441c4c4736b443fec6ac8deda4
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08283354B2

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