Ethyl 6-bromohexanoate → Ethyl 6-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)hexanoate

HRID 20662

Reaktionsgleichung

Reaktionsgleichung von HRID 20662
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8].[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([Cl:34])[C:18]=1[NH:19][C:20]1[C:29]2[C:24](=[C:25]([OH:32])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=2)[O:23][C:22](=[O:33])[CH:21]=1>>[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([Cl:34])[C:18]=1[NH:19][C:20]1[C:29]2[C:24](=[C:25]([O:32][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:26]([O:30][CH3:31])=[CH:27][CH:28]=2)[O:23][C:22](=[O:33])[CH:21]=1

Komponenten

3

Edukt 2

HCID 117544Ethyl 6-bromohexanoateHCID 248495704-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one

Produkt 1

HCID 24849664Ethyl 6-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)hexanoate

Versuchsvorschrift

The title compound was prepared from ethyl 6-bromohexanoate and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 9.51 (s, 1H), 8.81 (s, 2H), 7.94 (d, 1H), 7.20 (d, 1H), 4.63 (s, 1H), 4.02 (q, 2H), 3.97 (t, 2H), 3.91 (s, 3H), 2.39 (t, 2H), 1.67 (m, 2H), 1.57 (m, 2H), 1.46 (m, 2H), 1.15 (t, 3H); MS (ESI): 494.9.

Quellen und Nachweise

ORD-Eintrag
ord-971be59233fa44729fc045080b5484f5
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745646B2

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