Water → Ethyl 5-butoxy-1,3-oxazole-2-carboxylate
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:16])[C:5]([NH:7][CH2:8][C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])=[O:10])=O)[CH3:2].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.O>C(#N)C>[CH2:12]([O:11][C:9]1[O:10][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:16])=[N:7][CH:8]=1)[CH2:13][CH2:14][CH3:15]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
To a solution of butyl N-[ethoxy(oxo)acetyl]glycinate (783 g, 3.38 mol) in acetonitrile (8 L) in a 50 L glass reactor with overhead stirrer, phosphorus pentoxide (415 g, 2.92 mol) was added in portions. The reaction was heated at 60° C. for 1 hour. The product mixture was cooled, and water (8 L) was added with the mixture maintained at 20° C. The resultant mixture was extracted with dichloromethane (8 L, and 3 times 2 L). The organic extracts were combined, washed twice with saturated aqueous sodium bicarbonate (8 L total), dried over anhydrous magnesium sulfate, filtered and concentrated under vacuum. The residual oil was subjected to column chromatography on silica gel eluting with O-30% heptane/ethyl acetate gradient. Collection and concentration of appropriate fractions provided the title material.
Aufarbeitung
- temperatureThe product mixture was cooled
- temperaturemaintained at 20° C
- extractionThe resultant mixture was extracted with dichloromethane (8 L, and 3 times 2 L)
- washwashed twice with saturated aqueous sodium bicarbonate (8 L total)
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under vacuum
- customCollection and concentration of appropriate fractions
Quellen und Nachweise
- ORD-Eintrag
- ord-4f93ada854ae4051828ec0aec4c72fb9
- Quelldatensatz
- uspto-grants-2012_10
- Patentnummer
- US08293731B2
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