Acetic Anhydride → N-Benzyl-N-((E)-but-1-enyl)-acetamide

HRID 2066884Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2066884
[CH2:1]([NH:8]/[CH:9]=[CH:10]/[CH2:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C1(C)C=CC=CC=1>[CH2:1]([N:8](/[CH:9]=[CH:10]/[CH2:11][CH3:12])[C:20](=[O:22])[CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 15360338Benzyl-((E)-but-1-enyl)-amine

Produkt 1

HCID 13494620N-Benzyl-N-((E)-but-1-enyl)-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To 62a (3.22 g, 20 mmol) in 10 mL of toluene, was added triethylamine (2.79 mL, 20 mmol). The mixture was cooled to 0° C. and acetic anhydride (1.89 mL, 20 mmol) was added dropwise. The mixture was warmed to room temperature and stirred overnight. It was then concentrated on high vacuum to give crude 62b.

Aufarbeitung

  1. temperatureThe mixture was warmed to room temperature
  2. concentrationIt was then concentrated on high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-cd85b76f62644e16b5d6b84171cc7b09
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293729B2

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