Triphenylphosphine → HCID 55283830, Verbindung

HRID 2067339Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2067339
[N:1]([CH2:4][C:5]1[O:6][C:7]([CH:10]([F:12])[F:11])=[CH:8][CH:9]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1.O>[F:11][CH:10]([F:12])[C:7]1[O:6][C:5]([CH2:4][NH2:1])=[CH:9][CH:8]=1

Komponenten

5

Edukt 2

HCID 11776TriphenylphosphineHCID 866452892-(Azidomethyl)-5-(difluoromethyl)furan

Produkt 1

HCID 55283830HCID 55283830, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-(azidomethyl)-5-(difluoromethyl)furan (0.50 g, 2.92 mmol) in a mixture of tetrahydrofuran (10 mL) and water (1 mL) was added triphenylphosphine (1.15 g, 4.39 mmol). The reaction mixture was stirred at ambient temperature for 18 hours. The solvent was removed in vacuo and the residue was purified on strong cation exchange column to afford (5-(difluoromethyl)furan-2-yl)methanamine as a yellow oil in 70% yield (0.30 g): MS (ES+) m/z 3148.2 (M+1).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified on strong cation exchange column

Quellen und Nachweise

ORD-Eintrag
ord-1b6348d37c4c4b91ada149611453b441
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293768B2

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