Ethyl Acrylate → HCID 68706213, Verbindung

HRID 2069312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2069312
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[N:6][CH:7]=1.P.[CH2:16]([O:18][C:19](=[O:22])[CH:20]=[CH2:21])[CH3:17]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C(N(CC)CC)C>[CH2:16]([O:18][C:19](=[O:22])[CH:20]=[CH:21][C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)[CH3:17]

Komponenten

6

Edukt 3

HCID 8821Ethyl AcrylateHCID 24404PhosphineHCID 221807795-Bromo-2-(4-fluorophenyl)pyridine

Produkt 1

HCID 68706213HCID 68706213, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 167845palladium(II) acetateKatalysatorHCID 8471TriethylamineLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

9.30 g (36.9 mmol) of 5-bromo-2-(4-fluoro-phenyl)-pyridine were mixed with 100 ml of triethylamine, 2.06 g (9.2 mmol) of palladium acetate, 2.80 g (9.2 mmol) of tri)ortho-tolyl)phosphine and 6.47 g (64.6 mmol) of acrylic acid ethyl ester and heated to 90° C. for 2 h. The reaction mixture was evaporated, taken up in water and extracted with ethyl acetate. The combined organic phases were dried and evaporated, and the residue was subjected to column chromatography (silica gel, n-heptane/ethyl acetate 3:1). Yield: 7.7 g.

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. extractionextracted with ethyl acetate
  3. customThe combined organic phases were dried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d159d3ba97454be6a663c475ee9ec488
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299102B2

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