Sodium borohydride → 3-(4-Nitro-2-(trifluoromethyl)phenyl)propan-1-ol

HRID 2070030

Reaktionsgleichung

Reaktionsgleichung von HRID 2070030
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH:12]=[O:13])=[C:6]([C:14]([F:17])([F:16])[F:15])[CH:5]=1)([O-:3])=[O:2].[BH4-].[Na+]>CO>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][OH:13])=[C:6]([C:14]([F:15])([F:16])[F:17])[CH:5]=1)([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 231552963-(4-Nitro-2-(trifluoromethyl)phenyl)propionaldehyde

Produkt 1

HCID 593985353-(4-Nitro-2-(trifluoromethyl)phenyl)propan-1-olAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3-(4-Nitro-2-(trifluoromethyl)phenyl)propionaldehyde (1700 mg, 6.9 mmol) was dissolved in methanol (10 mL), and sodium borohydride (100 mg, 2.64 mmol) was added thereto. The mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure and then purified by silica-gel column chromatography (n-hexane:ethyl acetate=3:1) to give 3-(4-nitro-2-(trifluoromethyl)phenyl)propan-1-ol (859 mg, 50%) as a light-yellow oil.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. custompurified by silica-gel column chromatography (n-hexane:ethyl acetate=3:1)

Quellen und Nachweise

ORD-Eintrag
ord-9adc8069790e49a48fb0ac151e097f6f
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299252B2

Verknüpfte Notizen

Wird geladen…