4-Methoxypyrimidine-2-carbonitrile → (4-Methoxypyrimidin-2-yl)methanamine

HRID 2070969Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2070969
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]#[N:10])[N:4]=1>CO.[OH-].[NH4+].[Ni]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][NH2:10])[N:4]=1

Komponenten

5

Edukt 1

HCID 132211894-Methoxypyrimidine-2-carbonitrile

Produkt 1

HCID 59569974(4-Methoxypyrimidin-2-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittelHCID 14923Ammonium HydroxideLösungsmittel

Versuchsvorschrift

To 4-methoxypyrimidine-2-carbonitrile (370 mg) in MeOH (5 mL), aqueous ammonium hydroxide (1 mL) and Raney Nickel (catalytic) were added and the reaction mixture was hydrogenated at 55 psi for 2 h. Then the reaction mixture was filtered and solvent evaporated to afford (4-methoxypyrimidin-2-yl)methanamine, which was carried to next step without purification.

Aufarbeitung

  1. filtrationThen the reaction mixture was filtered
  2. customsolvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-96dbed3f826a40d8ae33ac82dd32bb24
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299267B2

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