3-(tert-Butyl)benzonitrile → (3-(tert-Butyl)phenyl)methanamine
Reaktionsgleichung
[C:1]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])([CH3:4])([CH3:3])[CH3:2]>CO.[OH-].[NH4+].[Ni]>[C:1]([C:5]1[CH:6]=[C:7]([CH2:8][NH2:9])[CH:10]=[CH:11][CH:12]=1)([CH3:4])([CH3:2])[CH3:3]Komponenten
5
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
To 3-tert-butylbenzonitrile (400 mg) in MeOH (5 mL), aqueous ammonium hydroxide (1 mL) and Raney Nickel (catalytic) were added and the reaction mixture was hydrogenated at 50 psi for 2 h. Then the reaction mixture was filtered and solvent evaporated. (3-tert-butylphenyl)methanamine was used without any purification.
Aufarbeitung
- filtrationThen the reaction mixture was filtered
- customsolvent evaporated
- custom(3-tert-butylphenyl)methanamine was used without any purification
Quellen und Nachweise
- ORD-Eintrag
- ord-bbc72d039ee94c15a853aef909dfd47b
- Quelldatensatz
- uspto-grants-2012_10
- Patentnummer
- US08299267B2
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