Brucine → HCID 18594875, Verbindung

HRID 2071342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2071342
[N:1]([CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1)=[N+]=[N-].COC1C=C2[C@@]34[C@@H]5C[C@H]6C(CN5CC3)=CCO[C@H]3CC(=O)N([C@H]4[C@@H]63)C2=CC=1OC>[Pd]>[NH2:1][CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1

Komponenten

4

Edukt 2

HCID 442021BrucineHCID 18594802HCID 18594802, Verbindung

Produkt 1

HCID 18594875HCID 18594875, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

A 1.06 g. sample of ethyl 15-azido-9-oxo-prostanoate (Example 110) is hydrogenated using 100 mg. of 5% palladium on carbon in 50 ml. absolute alcohol for 16 hours. The filtration of the catalyst and evaporation of the solvent affords an oil. Silica gel chromatography gives 604 mg. of oil; λ max. 2.95, 6.30 (brucine) and 5.72 μ (carbonyl groups).

Aufarbeitung

  1. filtrationThe filtration of the catalyst and evaporation of the solvent
  2. customaffords an oil
  3. customSilica gel chromatography gives 604 mg

Quellen und Nachweise

ORD-Eintrag
ord-f60c3c552dfc4ed5aa1086a1177ae164
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04046787

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