Hydrochloric Acid → HCID 21409930, Verbindung

HRID 2072000Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2072000
[CH2:1]([NH:3][CH2:4][C:5]1([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:2].[ClH:18]>CCOCC>[ClH:18].[ClH:18].[CH2:1]([NH:3][CH2:4][C:5]1([N:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21409899HCID 21409899, Verbindung

Produkt 1

HCID 21409930HCID 21409930, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 1-[1-(Ethylaminomethyl)cyclohexyl]-4-methyl piperazine (1.5 g.,) in ether (20 ml) was added excess of ethereal HCl. The suspension was evaporated to dryness and the residual oil was re-evaporated with ethanol/ether (x2). The residue was dissolved in a minimum amount of hot ethanol, the solution was cooled and excess isopropanol was added. The solid which separated was filtered and crystallised from ethanol/isopropanol to give 1-[1-(Ethylaminomethyl)cyclohexyl]-4-methyl piperazine, dihydrochloride (0.15 g.) m.p. 231°-234°.

Aufarbeitung

  1. customThe suspension was evaporated to dryness
  2. customthe residual oil was re-evaporated with ethanol/ether (x2)
  3. dissolutionThe residue was dissolved in a minimum amount of hot ethanol
  4. temperaturethe solution was cooled
  5. additionexcess isopropanol was added
  6. customThe solid which separated
  7. filtrationwas filtered
  8. customcrystallised from ethanol/isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-8e6e5a8dd7f0487cbb041623f4d4e820
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04049663

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