Water → 3Formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide

HRID 2072419

Reaktionsgleichung

Reaktionsgleichung von HRID 2072419
[CH:1]([NH:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([F:16])([F:15])[F:14])[CH:11]=2)[NH:6][N:5]=1)=[O:2].[CH3:17][N:18]([CH3:22])[C:19](Cl)=[O:20].O>N1C=CC=CC=1>[CH3:17][N:18]([CH3:22])[C:19]([N:6]1[C:7]2[C:12](=[CH:11][C:10]([C:13]([F:16])([F:14])[F:15])=[CH:9][CH:8]=2)[C:4]([NH:3][CH:1]=[O:2])=[N:5]1)=[O:20]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6598Dimethylcarbamoyl ChlorideHCID 21409159N-[5-(Trifluoromethyl)-1H-indazol-3-yl]formamide

Produkt 1

HCID 536971373Formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamideAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

0.2 mol of 3-formylamino-5-trifluoromethylindazole and 0.05 mol of dimethylcarbamic acid chloride in 20 ml of pyridine are heated for 4 hours to 50° C. After cooling, 150 ml of water are allowed to run in and the reaction product which has crystallized out is isolated by filtration. Recrystallization from ethanol gives 3formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide (melting point: 198°-200° C; 57% of theory).

Aufarbeitung

  1. temperatureAfter cooling
  2. customhas crystallized out
  3. customis isolated by filtration
  4. customRecrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-204b62a36e9e4f6490e59b9cf2f417f2
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04051252

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