Sulfuric Acid → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide

HRID 2072473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2072473
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:19][CH2:18][C:15]([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:16]#[N:17])[CH2:14][CH2:13]1.S(=O)(=O)(O)[OH:28].[OH-].[NH4+]>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:19][CH2:18][C:15]([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:16]([NH2:17])=[O:28])[CH2:14][CH2:13]1

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 537070301-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile

Produkt 1

HCID 214082231-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile (5.0 g) and 90% sulfuric acid (60.0 g) is heated for 10 minutes at 70° C. The mixture is then stirred at room temperature for an additional hour. The reaction mixture is poured into ice-water, basified with ammonium hydroxide, and extracted with chloroform. Concentration of the dried chloroform solution followed by trituration with benzene yields the title compound.

Aufarbeitung

  1. extractionextracted with chloroform

Quellen und Nachweise

ORD-Eintrag
ord-5252351b68534317b9ddf53e3f6ec849
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04051248

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