Hydrochloric Acid → HCID 131710913, Verbindung

HRID 2072488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2072488
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH2:8][CH2:7][CH2:6]2.[ClH:16].[CH3:17][NH:18][CH3:19].[CH2:20]=O.Cl>CC(C)=O.C(O)C>[ClH:16].[CH3:17][N:18]([CH2:20][CH:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:14])([F:15])[F:1])[CH:4]=2)[C:9]1=[O:13])[CH3:19]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 712Formaldehyde2×HCID 10473Dimethylamine, hydrochlorideHCID 149151176-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one

Produkt 1

HCID 131710913HCID 131710913, VerbindungAusbeute 77,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 6-(trifluoromethyl)-1-tetralone (0.90 g), dimethylamine hydrochloride (0.42 g), paraformaldehyde (0.16 g), and 95% ethanol (2 ml) containing concentrated hydrogen chloride (0.02 ml) is heated on a steam bath for 1 1/2 hours. The reaction mixture soon becomes homogeneous and the paraformaldehyde dissolves. The warm solution is diluted with acetone (15 ml) and cooled to yield the title compound as white needles (1.0 g) melting point 137°-138° C.

Aufarbeitung

  1. temperatureis heated on a steam bath for 1 1/2 hours
  2. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-d1e58b26508347cbbd8b91c582559e2c
Quelldatensatz
uspto-grants-1977_09
Patentnummer
US04051248

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