Ammonium Hydroxide → 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

HRID 2073184

Reaktionsgleichung

Reaktionsgleichung von HRID 2073184
[C:1]1([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]#[N:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:18].[NH4+]>S(=O)(=O)(O)O>[C:1]1([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([NH2:17])=[O:18])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 14804157-Phenylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

Produkt 1

HCID 145018607-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

A mixture of 4.0 g of 7-phenylpyrazolo[1,5-a]pyrimidine-3-carbonitrile (prepared as described in Example 7 of U.S. Pat. No. 4,236,005) and 40 ml of concentrated sulfuric acid was stirred at room temperature for 16 hours. The solution was then carefully poured into ice with stirring and the mixture was carefully made just basic with concentrated ammonium hydroxide. The solid was collected by filtration and recrystallized from dichloromethane to give pale yellow needles m.p. 236°-238.5° C.

Aufarbeitung

  1. customprepared
  2. additionThe solution was then carefully poured into ice
  3. filtrationThe solid was collected by filtration
  4. customrecrystallized from dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-6ce34974c9db43c5961da614671bb131
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04916137

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