HCID 85585332, Verbindung → HCID 11551221, Verbindung

HRID 2073515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2073515
[N:1]([CH2:4][CH2:5][O:6][C:7]1[CH:20]=[CH:19][C:10]([CH2:11][CH:12]2[S:16][C:15](=[O:17])[NH:14][C:13]2=[O:18])=[CH:9][CH:8]=1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH2:5][O:6][C:7]1[CH:20]=[CH:19][C:10]([CH2:11][CH:12]2[S:16][C:15](=[O:17])[NH:14][C:13]2=[O:18])=[CH:9][CH:8]=1

Komponenten

4

Edukt 1

HCID 85585332HCID 85585332, Verbindung

Produkt 1

HCID 11551221HCID 11551221, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 5-[4-(2-Azidoethoxy)Benzyl]2,4-Thiazolidinedione (5 g) in Methanol (100 ml) was reduced under hydrogen at ambient temperature and pressure in the presence of 10% palladium on charcoal (5 g) for 18 hours. The mixture was filtered through diatomaceous earth and the filter pad was washed exhaustively with Methanol. The combined filtrates was evaporated to dryness under reduced pressure and the title compound (m.p. 175°-6° C.) was obtained as a dihydrate following crystallisation from methanol.

Aufarbeitung

  1. customwas reduced under hydrogen at ambient temperature
  2. filtrationThe mixture was filtered through diatomaceous earth
  3. washthe filter pad was washed exhaustively with Methanol
  4. customThe combined filtrates was evaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f397d873a105467088b3b77f059efa28
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04918091

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