Water → Ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate

HRID 2073905Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2073905
[OH:1][C:2]1[CH:3]=[C:4]([C:8]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[CH:12]=2)=[O:9])[CH:5]=[CH:6][CH:7]=1.Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:9])[CH2:10][C:11]2[CH:12]=[C:13]([CH:14]=[CH:15][CH:16]=2)[O:17][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 147741341,2-Bis(3-hydroxyphenyl)ethanone

Produkt 1

HCID 14774136Ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 3,3'-dihydroxydeoxybenzoin (0.05 mol), ethyl bromoacetate (0.05 mol) ad K2CO3 (0.05 mol) in 50 mL of DMF is stirred at room temperature overnight. The reaction mixture is poured into water and extracted with EtOAc. The organic solution is dried and evaporated to dryness. The crude products are separtated by flash chromatography to give the ethyl 2-(3-(2-(3-hydroxyphenyl)-2-oxoethyl)phenoxy)acetate and the ethyl 2-(3-(2-(3-hydroxyphenyl)-1-oxoethyl)phenoxy)acetate.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. customThe organic solution is dried
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-64e78115bf9d4228913b449b8c0205a9
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04920131

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