Sodium Methoxide → HCID 19856565, Verbindung

HRID 2073930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2073930
[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5](S(C)=O)=[N:6][N:7]=1.[CH3:13][O-:14].[Na+]>CO>[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5]([O:14][CH3:13])=[N:6][N:7]=1

Komponenten

4

Edukt 2

HCID 10942334Sodium MethoxideHCID 198565676-Amino-4-methyl-3-methylsulfinyl-1,2,4-triazin-5-one

Produkt 1

HCID 19856565HCID 19856565, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

4.1 g of 6-amino-4-methyl-3-methylsulfinyl-1,2,4-triazin-5-one are suspended in 50 ml of absolute methanol, and 4.3 ml of 30% strength methanolic sodium methylate solution are added at room temperature. The reaction proceeds slightly exothermically and the temperature rises to 35° C. The solution is then stirred at 50° C. for 30 minutes, whereupon a colourless precipitate separates out of the clear yellow solution. The reaction miture is evaporated and the residue is taken up in ethyl acetate and ice-water. The organic phase is separated off, dried with magnesium sulfate and evaporated. The residue is washed with a little methanol and dried. 1.6 g of 6-amino-4-methyl-3-methoxy-1,2,4-triazin-5-one with a melting point of 198°-199° C. are obtained in this manner.

Aufarbeitung

  1. customrises to 35° C
  2. customThe reaction miture is evaporated
  3. customThe organic phase is separated off
  4. dry with materialdried with magnesium sulfate
  5. customevaporated
  6. washThe residue is washed with a little methanol
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4b383d0f487649a9b5b180571e7b17e7
Quelldatensatz
uspto-grants-1990_04
Patentnummer
US04920223

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