Sodium borohydride → tert-butyl (2S,3S)-1-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

HRID 2075378Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2075378
[Si:1]([O:8][CH2:9][C@@H:10]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[C@H:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=1)/[CH:12]=C/C)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[BH4-].[Na+].C[OH:36].C(Cl)Cl>>[Si:1]([O:8][CH2:9][C@@H:10]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:29])[CH3:30])[C@H:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][CH:16]=1)[CH2:12][OH:36])([C:4]([CH3:6])([CH3:7])[CH3:5])([CH3:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 4311764Sodium borohydrideHCID 21226129Dichloromethane methanolHCID 86613773tert-butyl (2S,3S,E)-1-(tert-butyldimethylsilyloxy)-3-(4-(trifluoromethyl)phenyl)hex-4-en-2-ylcarbamate

Produkt 1

HCID 57634005tert-butyl (2S,3S)-1-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamateAusbeute 97 %

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

tert-Butyl (2S,3S,E)-1-(tert-butyldimethylsilyloxy)-3-(4-(trifluoromethyl)phenyl)hex-4-en-2-ylcarbamate (2.0 g, 4.2 mmol) was taken up in 40 mL of 1:1 MeOH/DCM and the mixture was chilled to −78° C. Ozone was bubbled through the mixture until a blue color persisted. Nitrogen was then bubbled through the mixture for 15 minutes. NaBH4 (0.80 g, 21 mmol) was added, and the mixture was warmed to room temperature. After 3 hours, the mixture was quenched with aq NH4Cl. The mixture was extracted three times with 50 mL of DCM. The combined organic extracts were dried over MgSO4. Filtration and concentration under reduced pressure afforded tert-butyl (2S,3S)-1-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate (1.9 g, 97% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 7.56 (d, J=8.03 Hz, 2 H) 7.32 (d, J=8.03 Hz, 1 H) 4.51 (s, 1 H) 4.22-4.16 (m, 1H) 3.90-3.66 (m, 3H) 3.47 (d, J=5.52 Hz, 2 H) 3.15-3.20 (m, 1 H) 1.45 (s, 9 H) 0.84 (s, 9 H) 0.01 (s, 3H) −0.01 (s, 3H).

Aufarbeitung

  1. customOzone was bubbled through the mixture until a blue color
  2. customNitrogen was then bubbled through the mixture for 15 minutes
  3. temperaturethe mixture was warmed to room temperature
  4. customthe mixture was quenched with aq NH4Cl
  5. extractionThe mixture was extracted three times with 50 mL of DCM
  6. dry with materialThe combined organic extracts were dried over MgSO4
  7. filtrationFiltration and concentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-73d148bba354453bab35db21cbe419a3
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07919504B2

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