Ammonium Hydroxide → HCID 67089595, Verbindung
Reaktionsgleichung
[F:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]([NH:14][NH:15][C:16]([NH2:18])=[S:17])=O)=[CH:7][CH:6]=2.[OH-].[NH4+]>S(=O)(=O)(O)O>[F:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]1[S:17][C:16]([NH2:18])=[N:15][N:14]=1)=[CH:7][CH:6]=2Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 1-(3-fluoroisoquinoline-6-carbonyl)thiosemicarbazide (0.98 g, 3.71 mmol) in sulfuric acid (10 mL) was stirred at room temperature for 3 hours. The mixture was poured into ice-ammonium hydroxide (33%). The pH was adjusted to >9 with additional ammonium hydroxide. The precipitate was recovered by filtration and washed with water (4×) to provide the product as an off-white solid (0.84 g, 92%). LCMS (API-ES) m/z: 247 (M+H+).