Bromine → 6-Bromo-2-(3-methoxy-phenyl)-2-propyl-cyclohexanone

HRID 2075988Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2075988
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:16][CH2:17][CH3:18])[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])[CH:6]=[CH:7][CH:8]=1.[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:11]1[C:10](=[O:15])[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)([CH2:16][CH2:17][CH3:18])[CH2:14][CH2:13][CH2:12]1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 670959582-(3-Methoxy-phenyl)-2-propyl-cyclohexanone

Produkt 1

HCID 670961976-Bromo-2-(3-methoxy-phenyl)-2-propyl-cyclohexanoneAusbeute 94,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

2-(3-Methoxy-phenyl)-2-propyl-cyclohexanone (100 mg, 0.41 mmol) was dissolved in chloroform (1 mL). To this solution bromine (68.1 mg, 0.43 mmol) in chloroform (0.5 mL) was added drop wise at −11° C. The reaction was stirred at 5° C. for 1½ hours, at room temperature for 1 hour and at 50° C. for 1 hour. The solvent was removed under reduced pressure to yield the crude title compound (126 mg) which was used directly in the next step without further purification.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e2df7ad0133d4a8c94f57f5d9198a2f4
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07923450B2

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