Bromine → 6-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanone

HRID 2075992Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2075992
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]2=[O:16])=[CH:6][CH:5]=1.[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:12]1[C:11](=[O:16])[CH:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:17])([F:18])[F:1])=[CH:9][CH:8]=2)[CH2:15][CH2:14][CH2:13]1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 210825892-(4-Trifluoromethoxyl-phenyl)-cyclohexanone

Produkt 1

HCID 670961346-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanoneAusbeute 91,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

2-(4-Trifluoromethoxyl-phenyl)-cyclohexanone (53 mg, 0.21 mmol) was dissolved in chloroform (1 mL). To this solution bromine (34.4 mg, 0.22 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (65 mg) which was used directly in the next step without further purification.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9d1370a153124d72bfb1f0b3e567ff88
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07923450B2

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