Bromine → 6-Bromo-2-(2-chloro-phenyl)-cyclohexanone

HRID 2076000Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2076000
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=[O:14].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][CH:10]1[C:9](=[O:14])[CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH2:13][CH2:12][CH2:11]1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 43741102-(2-Chlorophenyl)cyclohexan-1-one

Produkt 1

HCID 670959316-Bromo-2-(2-chloro-phenyl)-cyclohexanoneAusbeute 112,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

2-(2-Chloro-phenyl)-cyclohexanone (51 mg, 0.25 mmol) was dissolved in chloroform (1 mL). To this solution bromine (42.3 mg, 0.27 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (81 mg) which was used directly in the next step without further purification.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3692381de02345ea9f4071bb1c056bd5
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07923450B2

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