tert-Butoxy bis(dimethylamino)methane → 6-[1-Dimethylamino-methylidene]-2-(2,4-dichloro-phenyl)-cyclohexanone
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].C(O[CH:21](N(C)C)[N:22]([CH3:24])[CH3:23])(C)(C)C>>[CH3:21][N:22]([CH3:24])[CH:23]=[C:11]1[C:10](=[O:15])[CH:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[CH2:14][CH2:13][CH2:12]1Komponenten
3
Versuchsvorschrift
2-(2,4-dichloro-phenyl)-cyclohexanone (101 mg, 0.42 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a) to give crude title compound (105 mg) as a red oil which was used directly in the next step. MS ISP (m/e): 298.3 [(M+H)+].
Quellen und Nachweise
- ORD-Eintrag
- ord-9be76db7ba004c96a6d8787a8d385ae2
- Quelldatensatz
- uspto-grants-2011_04