HCID 22291207, Verbindung → tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate

HRID 2076399Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2076399
C([N:8]1[CH2:23][CH2:22][CH2:21][C:9]21[CH2:13][N:12]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][CH2:10]2)C1C=CC=CC=1>CO.[Pd]>[CH2:13]1[C:9]2([CH2:21][CH2:22][CH2:23][NH:8]2)[CH2:10][CH2:11][N:12]1[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]

Komponenten

4

Edukt 1

HCID 22291207HCID 22291207, Verbindung

Produkt 1

HCID 22291199tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of t-butyl 6-benzyl-2,6-diazaspiro[4.4]nonane-2-carboxylate (1.70 g, 5.37 mmol) in methanol (30 mL) was mixed with 10% palladium on carbon (50 mg). The mixture was shaken under a hydrogen atmosphere (50 psi) in a Parr hydrogenation apparatus for 8 h and filtered through Celite. The filtrate was concentrated by rotary evaporation and high vacuum treatment, leaving 1.26 g of viscous, light brown oil (>100%), which was of sufficient purity to be used in the subsequent reaction.

Aufarbeitung

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation and high vacuum treatment

Quellen und Nachweise

ORD-Eintrag
ord-36f23253111147049028ec2887709e11
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07923559B2

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