Triphenylphosphine → HCID 57849580, Verbindung

HRID 2076799Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2076799
[C:1]([O:5][C:6](=[O:20])[N:7]([CH2:17][CH2:18][OH:19])[CH2:8][C@@H:9](O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>C1(C)C=CC=CC=1>[C:1]([O:5][C:6]([N:7]1[CH2:17][CH2:18][O:19][C@@H:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8]1)=[O:20])([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylateHCID 57849526HCID 57849526, Verbindung

Produkt 1

HCID 57849580HCID 57849580, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

3 g of (S)-(2-Hydroxy-ethyl)-(2-hydroxy-2-phenyl-ethyl)-carbamic acid tert-butyl ester and 0.327 g of triphenylphosphine were dissolved in 53.3 mL toluene. 0.217 g of diethylazodicarboxylate in 5.4 mL toluene was added dropwise to the resulting solution at room temperature under argon atmosphere and the mixture was stirred overnight. The solvent was removed in vacuo and the material purified by column chromatography.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe material purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-429c779d6e154ac886d5aaa0e1d71f96
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07928103B2

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