Dimethyl Sulfoxide → HCID 11949627, Verbindung

HRID 2077083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2077083
[Cl:1][C:2]1[N:9]=[C:8]([NH:10][C:11]2[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=2)[CH:7]=[C:6]([CH3:17])[C:3]=1[C:4]#[N:5].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][NH2:27])[CH:19]=1.C(=O)([O-])O.[Na+].CS(C)=O>O>[ClH:1].[ClH:1].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][NH:27][C:2]2[N:9]=[C:8]([NH:10][C:11]3[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=3)[CH:7]=[C:6]([CH3:17])[C:3]=2[C:4]#[N:5])[CH:19]=1

Komponenten

6

Edukt 4

HCID 679Dimethyl SulfoxideHCID 516892Sodium BicarbonateHCID 97937933-(2-Aminoethoxy)pyridineHCID 119835452-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile

Produkt 1

HCID 11949627HCID 11949627, VerbindungAusbeute 138,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

Compound A (13 g, 53 mmol), 2-(pyridin-3-yloxy)ethylamine (11 g, 80 mmol) and sodium hydrogencarbonate (45 g) were added to DMSO (130 ml), and the mixture was stirred at 130° C. for 20 hr. After stirring, the reaction mixture was added to cold water, and insoluble substance was filtrated (20 g). This was converted to hydrochloride to give the object compound of 2-(2-(pyridin-3-yloxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile dihydrochloride (15.5 g).

Aufarbeitung

  1. stirringAfter stirring
  2. filtrationwas filtrated (20 g)

Quellen und Nachweise

ORD-Eintrag
ord-eb8fd9396688484d9adf5635fd6883e7
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07928126B2

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