Ethylamine → N-ethyl-4-methoxybenzenesulfonamide

HRID 2077510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2077510
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH2:13]([NH2:15])[CH3:14]>C(Cl)Cl>[CH2:13]([NH:15][S:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)(=[O:11])=[O:10])[CH3:14]

Komponenten

4

Edukt 2

HCID 6341EthylamineHCID 74014-Methoxybenzenesulfonyl chloride

Produkt 1

HCID 4453230N-ethyl-4-methoxybenzenesulfonamideAusbeute 112 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Methoxybenzene-1-sulfonyl chloride (619.5 mg, 2.999 mmol) was dissolved in DCM (10 mL) and ethylamine (4.6 mL, 2.0 M in THF, 9.2 mmol) was added, and the reaction flask was put in a water bath and stirred under nitrogen. After stirring at RT over the weekend, the suspension was filtered, and the solid was washed with DCM. The filtrate was concentrated and dried under high vacuum to provide N-ethyl-4-methoxybenzenesulfonamide (723 mg, 89% yield). MS (ESI pos. ion) m/z: 216 (MH+). Calculated exact mass for C9H13NO3S: 215.

Aufarbeitung

  1. customthe reaction flask was put in a water bath
  2. stirringAfter stirring at RT over the weekend
  3. filtrationthe suspension was filtered
  4. washthe solid was washed with DCM
  5. concentrationThe filtrate was concentrated
  6. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-5cbd9edec7f444d98af3a89e42fafd73
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07928140B2

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