Methylamine → 5-Bromo-N-methyl-3-nitropyridin-2-amine

HRID 2077537

Reaktionsgleichung

Reaktionsgleichung von HRID 2077537
[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5](Cl)=[N:6][CH:7]=1.O1CCCC1.[CH3:17][NH2:18]>CO>[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH:18][CH3:17])=[N:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 70194125-Bromo-2-chloro-3-nitropyridine

Produkt 1

HCID 108681495-Bromo-N-methyl-3-nitropyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-bromo-2-chloro-3-nitropyridine (456 mg, 1920 μmol) was dissolved in MeOH (6.0 ml) and methylamine, 2.0 M solution in tetrahydrofuran (2.5 ml, 5.0 mmol) was added. The reaction was stirred at room temperature for 6 hours, allowed to stand at room temperature overnight, and then concentrated. material was taken directly to the next step.

Aufarbeitung

  1. waitto stand at room temperature overnight
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-477fb39ca8fe4324914ee8e5e98c1828
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07928140B2

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