Hydrazine hydrate (1:1) → 3-Fluoro-2-hydrazinylpyridine

HRID 2079157Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2079157
Cl[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>C(O)C>[F:8][C:7]1[C:2]([NH:10][NH2:11])=[N:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 27827912-Chloro-3-fluoropyridine

Produkt 1

HCID 269852863-Fluoro-2-hydrazinylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of 9.59 g of 2-chloro-3-fluoropyridine in 6 ml of ethanol there was added 6 ml of hydrazine monohydrate, and the mixture was stirred at 60° C. for 3 days. The solution was adsorbed onto 50g of NH silica gel and purified by NH silica gel column chromatography (ethyl acetate-heptane) to give the title compound (403 mg) as a yellow solid.

Aufarbeitung

  1. custompurified by NH silica gel column chromatography (ethyl acetate-heptane)

Quellen und Nachweise

ORD-Eintrag
ord-ac01dfd53aeb4404a69f9a0166566c9a
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07928228B2

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