HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 2079495Erstellt: 25. Oktober 2026
Thionyl Chloride → 4-tert-Butyl-N-[4-chloro-2-(chloro-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide
https://huagongshe.com/reaction/2079495
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Thionyl Chloride | HCID 24386 | — |
| Edukt | 4-tert-Butyl-N-[4-chloro-2-(hydroxy-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide | HCID 58646038 | — |
| Produkt | 4-tert-Butyl-N-[4-chloro-2-(chloro-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide | HCID 59485502 | — |
Reaktionsschritte
4-tert-Butyl-N-[4-chloro-2-(hydroxy-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide (1.1 g, 2.5 mmol) was dissolved in SOCl2 and heated at 80° C. overnight. Excess SOCl2 was removed by rotary evaporation. The residue suspended in 50 mL DCM was washed with saturated sodium bicarbonate solution (50 mL) and dried over MgSO4. Evaporation of solvent gave white crystalline solid. MS: (M+H)=450.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07932252B2 |
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| Quelldatensatz | uspto-grants-2011_04 |
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| ORD ID | ord-410e1da6702d48ffac7175cd0bc4b3ba |
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| Quellennotiz | uspto-grants-2011_04 |
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