Potassium Carbonate → 4-tert-Butyl-N-[4-chloro-2-(methoxy-pyridin-4-yl-methyl)-Phenyl]-benzenesulfonamide

HRID 2079496

Reaktionsgleichung

Reaktionsgleichung von HRID 2079496
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[CH:22](Cl)[C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:30](=O)([O-])[O-:31].[K+].[K+]>CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[CH:22]([O:31][CH3:30])[C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 594855024-tert-Butyl-N-[4-chloro-2-(chloro-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide

Produkt 1

HCID 597568654-tert-Butyl-N-[4-chloro-2-(methoxy-pyridin-4-yl-methyl)-Phenyl]-benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A suspension of 4-tert-butyl-N-[4-chloro-2-(chloro-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide (113 mg, 0.25 mmol) and potassium carbonate (69 mg, 0.5 mmol) in anhydrous methanol was heated at 60° C. overnight, the solid residue was then removed by filtration and product was purified by preparative HPLC. MS: (M+H)=445.

Aufarbeitung

  1. customthe solid residue was then removed by filtration and product
  2. customwas purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-8243154651194dda942bd5f33ca62a72
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932252B2

Verknüpfte Notizen

Wird geladen…