Hydrogen Bromide → 2-Amino-5-bromo-3-chlorobenzoic acid

HRID 2079625

Reaktionsgleichung

Reaktionsgleichung von HRID 2079625
[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 808072-Amino-3-chlorobenzoic acid

Produkt 1

HCID 8279792-Amino-5-bromo-3-chlorobenzoic acidAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a suspension of 2-amino-3-chlorobenzoic acid (2 g, 11.6 mmol) in chloroform (120 mL) was added dropwise bromine (1.1 equiv.) in chloroform (12 mL) solution. The mixture was stirred at room temperature for 16 hrs. The resulting white solid was collected by filtration and washed thoroughly with methylene chloride until the filtrate was colorless. The solid was air-dried to give 3.35 g of white powder as HBr salt of 2-amino-5-bromo-3-chlorobenzoic acid (87% yield). ES/MS m/z 250/252 (MH+).

Aufarbeitung

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed thoroughly with methylene chloride until the filtrate
  3. customThe solid was air-dried

Quellen und Nachweise

ORD-Eintrag
ord-3f417d96222c474b91be7cd3eaffa9f3
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932262B2

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