2-Nitro-4-trifluoromethylanisole → 2-Methoxy-5-(trifluoromethyl)aniline

HRID 2079681

Reaktionsgleichung

Reaktionsgleichung von HRID 2079681
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[N+:13]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:10])([F:11])[F:12])=[CH:5][C:4]=1[NH2:13]

Komponenten

4

Edukt 1

HCID 967482-Nitro-4-trifluoromethylanisole

Produkt 1

HCID 6006372-Methoxy-5-(trifluoromethyl)anilineAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-methoxy-3-nitrobenzotrifluoride and 10% of 10% Pd/C in methanol was stirred under H2 atmosphere overnight at room temperature. The reaction mixture was filtered through celite, concentrated and dried under vacuum to provide product as an off white solid in 99% yield. ES/MS m/z 192.1 (MH+).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationconcentrated
  3. customdried under vacuum
  4. customto provide product as an off white solid in 99% yield

Quellen und Nachweise

ORD-Eintrag
ord-0e11a43a96194bd6b45518dc8d910a74
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932262B2

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