3-(2-Methylpropenyl)-benzylamine → 3-Isobutylbenzylamine

HRID 2080137

Reaktionsgleichung

Reaktionsgleichung von HRID 2080137
[CH3:1][C:2]([CH3:12])=[CH:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8]>C(O)C.[C].[Pd]>[CH2:3]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8])[CH:2]([CH3:12])[CH3:1]

Komponenten

4

Edukt 1

HCID 231307203-(2-Methylpropenyl)-benzylamine

Produkt 1

HCID 231305533-IsobutylbenzylamineAusbeute 56,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

3-(2-Methylpropenyl)-benzylamine described in Preparation Example 137 (100 mg, 0.621 mmol) was dissolved in ethanol (5 mL), 10% palladium-carbon (50% water wet, 20 mg) was added thereto, and the mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. The catalyst was filtered, then, the solvent was evaporated, and the title compound (58 mg, 56.6%) was obtained as a colorless oil.

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-f49fab2946984f2d92c5d12888688d44
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932272B2

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