Nitric Acid → HCID 57433540, Verbindung

HRID 2080665Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2080665
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9].C(=O)([O-])[O-].[Na+].[Na+]>O>[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 10340Sodium CarbonateHCID 57433539Methyl 2-fluoro-4-[(pyridine-2-carbonyl)amino]benzoate

Produkt 1

HCID 57433540HCID 57433540, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

With cooling with ice, 110 ml of fuming nitric acid was gradually added to 27.7 g of methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate, and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to a solution of sodium carbonate (138 g) in water (2000 ml), and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 27.5 g of the entitled compound as a yellow solid.

Aufarbeitung

  1. temperatureWith cooling with ice
  2. customthe reaction liquid
  3. filtrationthe formed solid was taken out through filtration
  4. customThis was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-870e307c5bb8410aaae104a10e2bf771
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932394B2

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