Methanol → {3-[6-(4-Aminomethyl-phenyl)-pyridin-2-yl]-propyl}-dipropyl-amine

HRID 2080806Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2080806
CO.[CH2:3]([N:6]([CH2:34][CH2:35][CH3:36])[CH2:7][CH2:8][CH2:9][C:10]1[N:15]=[C:14]([C:16]2[CH:33]=[CH:32][C:19]([CH2:20][N:21]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:18][CH:17]=2)[CH:13]=[CH:12][CH:11]=1)[CH2:4][CH3:5].O.NN>C(Cl)(Cl)Cl>[NH2:21][CH2:20][C:19]1[CH:32]=[CH:33][C:16]([C:14]2[N:15]=[C:10]([CH2:9][CH2:8][CH2:7][N:6]([CH2:34][CH2:35][CH3:36])[CH2:3][CH2:4][CH3:5])[CH:11]=[CH:12][CH:13]=2)=[CH:17][CH:18]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 24654Hydrazine hydrate (1:1)HCID 231554522-{4-[6-(3-Dipropylamino-propyl)-pyridin-2-yl]-benzyl}-isoindol-1,3-dione

Produkt 1

HCID 23155536{3-[6-(4-Aminomethyl-phenyl)-pyridin-2-yl]-propyl}-dipropyl-amineAusbeute 105,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A methanol solution (2.0 ml) containing the compound (40.0 mg) obtained in Example 36-4 was added with hydrazine monohydrate (44 mg) and the whole was stirred at 60° C. for 1.5 hours, followed by distillating off the solvent. The residue was dissolved in chloroform and filtrated through Celite, the solvent was distilled off, thereby obtaining the subject compound (30.1 mg) as an amber liquid.

Aufarbeitung

  1. filtrationfiltrated through Celite
  2. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-e296b3619ace4450931041a4571e2bfa
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932281B2

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