Hydrochloric Acid → HCID 11670688, Verbindung

HRID 2080855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2080855
C[O:2][C:3](=[O:38])[CH2:4][N:5]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH2:32][C:33]2[NH:34][CH:35]=[CH:36][N:37]=2)[CH2:26][C:27]2[NH:28][CH:29]=[CH:30][N:31]=2)=[CH:20][CH:19]=1)[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13].Cl>O>[NH:28]1[CH:29]=[CH:30][N:31]=[C:27]1[CH2:26][N:25]([CH2:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:5]([CH2:4][C:3]([OH:38])=[O:2])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])=[CH:19][CH:20]=1)[CH2:32][C:33]1[NH:37][CH:36]=[CH:35][N:34]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 11533761HCID 11533761, Verbindung

Produkt 1

HCID 11670688HCID 11670688, VerbindungAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The compound (533.4 mg) obtained in Example 68-1 was dissolved in water (0.5 ml) and added with concentrated hydrochloric acid (2.5 ml). The whole was refluxed under heating for 30 minutes. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (384.1 mg) of the subject compound as a white solid.

Aufarbeitung

  1. temperatureThe whole was refluxed
  2. temperatureunder heating for 30 minutes
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-4da547024b0c4f808c8a0afcbe4ccb63
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932281B2

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