2-(4-Nitro-3-pentafluorosulfanylphenyl)isoindole-1,3-dione → 2-(4-Amino-3-pentafluorosulfanylphenyl)isoindole-1,3-dione

HRID 2080932Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2080932
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:20])=[CH:6][C:5]=1[S:21]([F:26])([F:25])([F:24])([F:23])[F:22])([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:20])=[CH:6][C:5]=1[S:21]([F:26])([F:25])([F:22])([F:23])[F:24]

Komponenten

5

Edukt 2

HCID 596421452-(4-Nitro-3-pentafluorosulfanylphenyl)isoindole-1,3-dioneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 596421372-(4-Amino-3-pentafluorosulfanylphenyl)isoindole-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.94 g (4.92 mmol) of 2-(4-nitro-3-pentafluorosulfanylphenyl)isoindole-1,3-dione (prepared in example 4) were dissolved in 20 ml of methanol, admixed with 10% palladium on activated carbon and hydrogenated at room temperature at a hydrogen pressure of 5 bar. On completion of reaction, the catalyst was filtered off and the filtrate concentrated. The residue was stirred in a mixture of dichloromethane and n-heptane, filtered with suction and dried under reduced pressure. 2-(4-amino-3-pentafluorosulfanylphenyl)isoindole-1,3-dione having a melting point of 176-178° C. was obtained.

Aufarbeitung

  1. customOn completion of reaction
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate concentrated
  4. filtrationfiltered with suction
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-867befe0c3dd4f7e94a4571ad9c3fde5
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932416B2

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