Carbon Dioxide → Sodium Phenylacetate

HRID 2083130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2083130
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:8].[Na].C1(C)C=CC=CC=1[Na:16].C([Na])C1C=CC=CC=1.[C:26](=[O:28])=[O:27].[C]=O>>[C:3]1([CH2:8][C:26]([O-:28])=[O:27])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1.[Na+:16]

Komponenten

7

Edukt 6

HCID 280Carbon DioxideHCID 72382-ChlorotolueneHCID 5360545SodiumHCID 178418416HCID 178418416, VerbindungHCID 178424341HCID 178424341, VerbindungHCID 178507086HCID 178507086, Verbindung

Produkt 1

HCID 23690424Sodium Phenylacetate

Versuchsvorschrift

In the preferred embodiments of the present invention, chlorotoluene is contacted with sodium which is dispersed in an inert organic solvent at 0° C to 50° C, preferably 10° C to 40° C for 5 minutes to 2 hours preferably about 30 minutes to 1 hour. Thereafter, rearrangement of the tolylsodium to benzylsodium is accomplished by heating the reaction mixture to 40° C to 150° C, preferably 50° C to 120° C for 1 hour to 10 hours preferably 3 hours to 7 hours. After the rearrangement reacting, carbon dioxide gas is introduced into the reaction mixture at room temperature or solid carbon oxide is added to the reaction mixture at room temperature and then the reaction is conducted to produce sodium phenylacetate. Thereafter, a mineral acid is added to the reaction mixture to produce phenylacetic acid; as shown in the first embodiment.

Aufarbeitung

  1. additionis dispersed in an inert organic solvent at 0° C to 50° C, preferably 10° C to 40° C for 5 minutes to 2 hours preferably about 30 minutes to 1 hour
  2. temperatureby heating the reaction mixture to 40° C to 150° C
  3. waitpreferably 50° C to 120° C for 1 hour to 10 hours preferably 3 hours to 7 hours

Quellen und Nachweise

ORD-Eintrag
ord-1788e3a0b5c9459995eec9821ed7afa0
Quelldatensatz
uspto-grants-1978_04
Patentnummer
US04084061

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