Ethyl bromoacetate → {[6,7-Dichloro-2-methyl-1-oxo-2-(propan-2-yl)-2,3-dihydro-1H-inden-5-yl]oxy}acetic acid
Reaktionsgleichung
[CH3:1][C:2]1([CH:15]([CH3:17])[CH3:16])[CH2:10][C:9]2[C:4](=[C:5]([Cl:13])[C:6]([Cl:12])=[C:7]([OH:11])[CH:8]=2)[C:3]1=[O:14].C(=O)([O-])[O-].[K+].[K+].Br[CH2:25][C:26]([O:28]CC)=[O:27].[OH-].[Na+]>CN(C=O)C.O>[O:14]=[C:3]1[C:4]2[C:9](=[CH:8][C:7]([O:11][CH2:25][C:26]([OH:28])=[O:27])=[C:6]([Cl:12])[C:5]=2[Cl:13])[CH2:10][C:2]1([CH3:1])[CH:15]([CH3:17])[CH3:16]Komponenten
7
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 55 °C
Versuchsvorschrift
A stirred mixture of 2-methyl-2-isopropyl-5-hydroxy-6,7-dichloro-1-indanone (6.2 g., 0.023 mole), potassium carbonate (7.3 g.), ethyl bromoacetate (8.5 g.) in DMF (70 ml.) is warmed in an inert atmosphere at 55° C. for one hour, then treated with water (60 ml.) and 10N sodium hydroxide (10 ml.) and heated on a steam bath for 1.5 hours. The reaction mixture is poured into water, acidified, extracted with ether, washed with water and dried over magnesium sulfate. Following evaporation of the ether there is obtained 5.1 g. of (1-oxo-2-methyl-2-isopropyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 156°-157° C. after recrystallization from nitromethane.
Aufarbeitung
- temperatureheated on a steam bath for 1.5 hours
- extractionextracted with ether
- washwashed with water
- dry with materialdried over magnesium sulfate
- customevaporation of the ether
- customthere is obtained 5.1 g
- customof (1-oxo-2-methyl-2-isopropyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 156°-157° C. after recrystallization from nitromethane
Quellen und Nachweise
- ORD-Eintrag
- ord-9df0cd6ccff54f1f9ef69da4875b8383
- Quelldatensatz
- uspto-grants-1978_04
- Patentnummer
- US04085219
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