Oxalyl chloride → 2-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride

HRID 20835

Reaktionsgleichung

Reaktionsgleichung von HRID 20835
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([C:16]([F:19])([F:18])[F:17])[C:4]=1[C:5](O)=[O:6].C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([C:16]([F:19])([F:18])[F:17])[C:4]=1[C:5]([Cl:23])=[O:6]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 27412872-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

Produkt 1

HCID 179993452-Methoxy-4,6-bis(trifluoromethyl)benzoyl chlorideAusbeute 109,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2-(methyloxy)-4,6-bis(trifluoromethyl)benzoic acid (20.2 g; 70.14 mmol) in dry DCM (400 mL), at 0° C., was added dropwise oxalyl chloride (13.4 mL; 154.31 mmol) followed by dry DMF (5 drops). The reaction was allowed to reach room temperature. After overnight stirring the solvent was evaporated in vacuo to get the title product (23.5 g) as a yellow slurry used without further purification.

Aufarbeitung

  1. customto reach room temperature
  2. customwas evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-865399f9efde4960829c7c9e0ae9bec4
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745642B2

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