Hydrochloric Acid → L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

HRID 2083822Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2083822
CO.[ClH:3].[CH3:4][O:5][C:6](=[O:47])[C@H:7]([CH2:39][C:40]1[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=1)[NH:8][C:9](=[O:38])[C@H:10]([CH2:36][OH:37])[NH:11][C:12](=[O:35])[C@H:13]([CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)[NH:14]C(OCC1C=CC=CC=1)=O>O1CCCC1.[Pd]>[ClH:3].[CH3:4][O:5][C:6](=[O:47])[C@H:7]([CH2:39][C:40]1[CH:41]=[CH:42][C:43]([OH:46])=[CH:44][CH:45]=1)[NH:8][C:9](=[O:38])[C@H:10]([CH2:36][OH:37])[NH:11][C:12](=[O:35])[C@H:13]([CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)[NH2:14]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54186548HCID 54186548, Verbindung

Produkt 1

HCID 70617527L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methanol (75 ml.) containing 1.7 ml. of 3N hydrogen chloride in tetrahydrofuran is added to a mixture of 3.1 g. of Nα -benzyloxycarbonyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester and 200 mg. of 20% palladium-on-carbon and the reaction is stirred under an atmosphere of hydrogen for two and a half hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated under reduced pressure to give a residue of L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6c77b608e8c14205a382810b8a848044
Quelldatensatz
uspto-grants-1978_04
Patentnummer
US04086219

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