Hydrazine hydrate (1:1) → HCID 178434196, Verbindung

HRID 2084290

Reaktionsgleichung

Reaktionsgleichung von HRID 2084290
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][C:7]([CH3:12])([CH3:11])[CH2:6][C:5]1=O)(=O)[CH3:2].O.[NH2:15][NH2:16]>C(O)C>[CH3:2][C:1]1[C:4]2[C:9](=[O:10])[CH2:8][C:7]([CH3:12])([CH3:11])[CH2:6][C:5]=2[NH:16][N:15]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 5194481,3-Cyclohexanedione, 2-acetyl-5,5-dimethyl-

Produkt 1

HCID 178434196HCID 178434196, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-acetyl-5,5-dimethyl-cyclohexane-1,3-dione (2 g, 11.04 mmol), prepared as described in example 2, and hydrazine hydrate (1.66 ml, 33.13 mmol) in ethanol (25 ml) was stirred at room temperature for about 3 hours and then the solvent was evaporated. The residue was dissolved in dichloromethane, washed with water and brine, dried over sodium sulfate and evaporated. The title compound was obtained after chromatography on silica gel (dichloromethane:methanol=95:5) as a colourless solid (0.8 g, 45%): m.p. 103-104° C.

Aufarbeitung

  1. customprepared
  2. customthe solvent was evaporated
  3. dissolutionThe residue was dissolved in dichloromethane
  4. washwashed with water and brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-7341d36ebd6943d69784ba4eecbad69a
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06716856B1

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