Hydrochloric Acid → 2-(2'-Hydroxystyryl)benzothiazole

HRID 2085168

Reaktionsgleichung

Reaktionsgleichung von HRID 2085168
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH3:10][C:11]1[S:12][CH:13]=[CH:14][N:15]=1.Cl.[OH-].[K+]>>[OH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[CH:1]=[CH:10][C:11]1[S:12][C:13]2[CH:7]=[CH:8][CH:2]=[CH:1][C:14]=2[N:15]=1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 6998SalicylaldehydeHCID 14797Potassium HydroxideHCID 771292-Methylthiazole

Produkt 1

HCID 1363860142-(2'-Hydroxystyryl)benzothiazoleAusbeute 39,5 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Salicylaldehyde (6.1 g) and 2-methylthiazole (7.5 g) were mixed and conc. hydrochloric acid (1.5 ml) was added thereto. The mixture was stirred with heating at 100° C. for 9 hr. The reaction mixture was cooled, and aqueous potassium hydroxide solution was added. The aqueous layer was washed with ether and made acidic with hydrochloric acid and extracted again with ethyl acetate. The organic solvent was dried and concentrated to give the title compound (2.5 g) as pale-yellow crystals, melting point 235-236° C.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. washThe aqueous layer was washed with ether
  3. extractionextracted again with ethyl acetate
  4. customThe organic solvent was dried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9d7606613c5042dea87c697bd46c9e03
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06720320B2

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