Sodium Methoxide → 4-Chloro-2-methoxymethylpyridine
Reaktionsgleichung
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9]Cl)[CH:4]=1.[CH3:11][O-:12].[Na+]>CO>[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][O:12][CH3:11])[CH:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
A mixture of 4-chloro-2-chloromethylpyridine hydrochloride (0.43 g), sodium methoxide (1.11 g) and methanol (15 ml) was stirred at room temperature for 10 hours and at 70° C. for 7 hours. The reaction mixture was concentrated, and the residue was combined with water and methylene chloride, and the organic phase was separated. After washing with saturated aqueous sodium bicarbonate followed by drying and concentrating, a title compound (0.28 g) was obtained as a tan oil.
Aufarbeitung
- concentrationThe reaction mixture was concentrated
- customthe organic phase was separated
- washAfter washing with saturated aqueous sodium bicarbonate
- customby drying
- concentrationconcentrating
Quellen und Nachweise
- ORD-Eintrag
- ord-01b252892f29416aba673e6e2f47436c
- Quelldatensatz
- uspto-grants-2004_04
- Patentnummer
- US06723722B1
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