Water → 1-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-1H-benzotriazole

HRID 2088416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2088416
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1.Cl.Cl[CH2:12][C:13]1[CH:14]=[C:15]([C:19]2[N:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:21][N:20]=2)[CH:16]=[CH:17][CH:18]=1.C(=O)([O-])O.[Na+].O>C(#N)C>[N:28]1([CH2:27][CH2:26][O:25][C:22]2[CH:23]=[N:24][C:19]([C:15]3[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=3)[CH2:12][N:1]3[C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[N:3]=[N:2]3)=[N:20][CH:21]=2)[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 669855014-{2-[2-(3-Chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochlorideHCID 178418385HCID 178418385, Verbindung

Produkt 1

HCID 461793741-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-1H-benzotriazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

49 mg (0.41 mmol) of 1H-benzotriazole, 150 mg (0.41 mmol) of 4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochloride and 136 mg (1.62 mmol) of sodium hydrogencarbonate are suspended in 4 ml of acetonitrile and stirred at 90° C. for 18. Water is added to the reaction mixture, which is then extracted with ethyl acetate. The organic phase is dried over sodium sulfate, evaporated and purified by means of column chromatography on silica gel.

Aufarbeitung

  1. extractionis then extracted with ethyl acetate
  2. dry with materialThe organic phase is dried over sodium sulfate
  3. customevaporated
  4. custompurified by means of column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-322349e51c6540eeab3b66a35f6ff41f
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08435986B2

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