Hydrochloric Acid → HCID 67228770, Verbindung

HRID 2088664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2088664
C(OC([NH:8][C:9]1[N:14]=[C:13]([NH:15][CH:16]2[CH2:21][CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17]2)[CH:12]=[CH:11][C:10]=1[C:29](=[O:32])[CH2:30][CH3:31])=O)(C)(C)C.[ClH:33]>O1CCOCC1.C(OCC)C>[ClH:33].[NH2:8][C:9]1[C:10]([C:29](=[O:32])[CH2:30][CH3:31])=[CH:11][CH:12]=[C:13]([NH:15][CH:16]2[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]2)[N:14]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 57911742tert-Butyl 3-({6-[(tert-butoxycarbonyl)amino]-5-propanoylpyridin-2-yl}amino)piperidine-1-carboxylate

Produkt 1

HCID 67228770HCID 67228770, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

380 mg (0.85 mmol) of tert-butyl 3-({6-[(tert-butoxycarbonyl)amino]-5-propanoylpyridin-2-yl}amino)piperidine-1-carboxylate (Example 26A) were dissolved in 10 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 20 h. After the reaction had gone to completion, the reaction mixture was diluted with diethyl ether (100 ml), and the recipitate was filtered off and washed with diethyl ether (100 ml) and dried. This gave 170 mg (70% of theory) of the product as a solid.

Aufarbeitung

  1. filtrationthe recipitate was filtered off
  2. washwashed with diethyl ether (100 ml)
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b65d0146f27b46f28bc42372a1a9291e
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436003B2

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