Water → 5-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine

HRID 2088972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2088972
[Br:1][C:2]1[C:3]([CH3:11])=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[Cl:12]N1C(=O)CCC1=O.O>O1CCCC1>[Br:1][C:2]1[C:3]([CH3:11])=[C:4]2[C:10]([Cl:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 401522575-bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 534129335-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridineAusbeute 96,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The compound obtained in Step 3 of Example 36 (323 mg) was dissolved in tetrahydrofuran (6 ml). N-Chlorosuccinimide (225 mg) was added and the mixture was stirred at room temperature for three days. Water was added to the reaction solution, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated to give the title compound (364 mg).

Aufarbeitung

  1. extractionfollowed by extraction with chloroform
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-58a52b4aa75a439eba2f2414f9bf642e
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436012B2

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